The present studies were conducted to show the potential of 2D zeolites as eective and\nnon-toxic carriers of drugs. Layered zeolites exhibit adjustable interlayer porosity which can be\nexploited for controlled drug delivery allowing detailed investigation of the drug release because the\nstructure of the carrier is known exactly. This study was conducted with model drugs ciprofloxacin\nand piracetam, and ZSM-55 with ca 1 nm thick layers, in detemplated and pillared forms. The release\nprofiles differed from the commercial, crystalline forms of drugsâ??the release rate increased for\nciprofloxacin and decreased for piracetam. To understand the dissolution mechanisms the release\ndata were fitted to Korsmeyer-Peppas equation, showing Fickian (for pillared) and anomalous (for\ndetemplated sample) transport. FT-IR studies showed that strong interaction carrier-drug may be\nresponsible for the modified, slowed down release of piracetam while better solubility and faster\nrelease of ciprofloxacin was attributed to formation of the protonated form resulting in weaker\ninteraction with the zeolite than in the pure crystalline form. Two independent tests on L929 mice\nfibroblasts (ToxiLight and PrestoBlue) showed that ZSM-55, in moderate concentrations may be safely\nused as a carrier of drug molecules, not having negative effect on the cells viability or proliferation rate.
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